Which substances are typically associated with polyuria?

Polyuria, which refers to the passage of abnormally large volumes of urine, is commonly linked to the use of diuretics. Diuretics are medications that promote diuresis, the increased production of urine by the kidneys. They work by influencing kidney function, either by inhibiting the reabsorption of sodium and water in the renal tubules or by directly affecting renal blood flow, thereby increasing urine output.

In the context of this question, diuretics are intended to reduce fluid retention and are often prescribed for conditions such as hypertension and edema. As a result, they lead to a notable increase in urine volume, which aligns directly with the definition of polyuria.

Other substances like electrolytes, nutrients, and proteins may play roles in a variety of medical conditions, but they do not directly cause the pronounced increase in urine output associated with polyuria in the same way that diuretics do. Electrolytes can affect fluid balance, but they are not substances that inherently lead to increased urine production as a primary action, nor do nutrients or proteins induce polyuria.